NativeSkin® Human Skin Models

LIVE HUMAN SKIN ADAPTED TO YOUR NEEDS

REAL HUMAN SKIN STRUCTURE

NativeSkin models hold normal skin barrier function, a mature stratum corneum, a functional basal layer and all cell types and skin appendages of in vivo human skin.

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LIVE HUMAN SKIN RESPONSE

After 7 days of culture, NativeSkin models still reflect the same histological features as in vivo human skin to allow for repeated testing.

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READY. EASY. STANDARDIZED.

NativeSkin is designed as a ready-to-use testing kit for easy manipulation. Production is standardized for reproducible results.

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ADAPTED TO YOUR NEEDS

NativeSkin can be used for both systemic and topical applications, without leaking into the medium.

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NativeSkin

The last-line screens prior to clinical evaluation

NativeSkin is a patented human skin model to simplify the culture, treatment and manipulation of human skin for research and analysis. NativeSkin kits contain round human skin biopsies from surgical residue donated by adult volunteers. Every individual skin biopsy is embedded in a high-tech solid matrix that maintains and nourishes the skin during shipment. A chemically defined animal component-free (ACF) / xeno-free (XF) skin culture medium is also provided in the kit that needs to be changed every day to keep the skin biopsies alive for 7 days. NativeSkin helps you avoid animal experimentation and represents a highly predictive and cost-effective last-line screen in laboratory conditions prior to in vivo clinical evaluations.

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Applications

The culture of skin explants has a long tradition in investigative dermatology to study the physiology and pathophysiology of human skin and epidermal appendages in vitro. NativeSkin is relevant for the following applications:

Efficacy testing, Topical application, Dermal studies, Epidermal studies, Percutaneous absorption, Metabolism, Long term studies, Repeated dose assay, Langerhans cells study, Skin resident T cells study, Immune responses, Melanogenesis, Melanocyte study

Approved protocols

Genoskin has approved different protocols to analyze the effects of a treatment or compound on NativeSkin models:

MTT-based cell viability assay, Formalin fixation for paraffin embedding, Epidermal separation with Dispase, Immunofluorescence, ELISA, Transdermal permeation assays, RNA extraction, Protein extraction

FOR MORE DETAILED PROTOCOLS...

Please don’t hesitate to contact us.

NativeSkin is available in 4 different sizes

Genoskin inserts

NativeSkin comes in different sizes and versions to answer all your study and assay requirements.

The standard version of NativeSkin models is designed for skin absorption studies and contains a white silicone ring that is firmly fixed to the skin biopsy. This silicone ring covers the outer edge of the biopsy to prevent lateral diffusion of topically applied products. A more basic version and a smaller model (NativeSkin S), without the silicone ring, are also available and designed for systemic treatments and genomic readout. Below you will find an overview of our entire range of NativeSkin products.

REFERENCE DESCRIPTION WORKING SURFACE RECOMMENDED TOPICAL VOLUME EX VIVO CULTURE DURATION PLATE FORMAT REQUIRED VOLUME MINIMUM ORDER
NS001 NativeSkin Basic (without silicone ring) 0.5 cm2 7 days 12 wells 1mL 12 wells
NS002 NativeSkin 0.5 cm2 10-20uL 7 days 12 wells 1mL 12 wells
NS003 NativeSkin Large 1.76 cm2 50-70uL 7 days 6 wells 2mL 12 wells
NS004 NativeSkin XL 2.54 cm2 100-200uL 5 days 6 wells 3mL 12 wells
NS005 NativeSkin S (without silicone ring) 0.38 cm2 7 days 24 wells 1mL 12 wells

FOR DETAILED QUOTATIONS

Please don’t hesitate to contact us. Special conditions may apply for academic research projects.