OncoSkin® skin cancer model
LIVE HUMAN MELANOMA SKIN CANCER MODEL
REAL HUMAN SKIN MICROENVIRONMENT
Test your skin cancer treatments on an ex vivo skin model that includes the skin’s microenvironment.
REAL HUMAN SKIN STRUCTURE
The OncoSkin skin cancer model contains all the human skin layers, cells and appendages.
LIVE HUMAN SKIN RESPONSE
Genoskin’s patented matrix and culture medium keep the skin model alive for up to 7 days.
PROJECT UNDER DEVELOPMENT
OncoSkin is currently under development.
A human skin model to study melanoma skin cancer
Genoskin is developing a new skin cancer model for the in vitro study of melanoma. Patients who suffer from this highly dangerous type of skin cancer currently have limited therapeutic options when the cancer reaches metastasis. The OncoSkin® skin cancer model now enables in vitro studies on live melanoma spheroids implanted in donated human skin tissue in order to develop new drug therapies and study other therapeutic options.
The need for better skin cancer models
Science currently uses in vitro models, such as multicellular tumor spheroids, to develop anti-tumor drugs. These cancer models mimic the 3D organization and heterogeneity of tumors but do not take into account the interaction between the tumor and its micro-environment, even though this interaction plays a key role in tumor growth and metastasis development. To better understand molecular and cellular events and develop efficient therapies, there is a clear need for experimental skin models that closely mimic the tissue environment of melanoma lesions.
OncoSkin: a model for melanoma
The OncoSkin® skin cancer model uses donated human skin tissue that is kept alive in a specifically designed matrix and culture medium. A melanoma spheroid is implanted directly into the live human skin biopsy to enable melanoma cells to interact with the skin’s micro-environment, where they normally develop and grow. This innovative and patented approach may allows the dynamic study of melanoma cell invasion in situ, if the ex vivo human skin biopsy can maintain cellular viability and tissue integrity for several days. The OncoSkin® melanoma model may offers an innovative and standardized approach to test and further develop reference drugs, such as Vemurafenib, as well as other drug candidates.