SKIN MODEL FOR SUBCUTANEOUS INJECTIONS
NEW SUBCUTANEOUS INJECTIONS STUDY MODEL
HypoSkin is currently the only alternative to animal testing for subcutaneous injections.
INJECTABLE REAL HUMAN SKIN
The HypoSkin model contains all three layers of human skin for predictive studies.
LIVE HUMAN SKIN RESPONSE
Genoskin’s patented matrix and culture medium keep the skin model alive for up to 7 days.
ADAPTED TO YOUR NEEDS
HypoSkin is available in different formats and can be used for subcutaneous and topical applications.
The need for in vitro models for subcutaneous injections
To date, there are no in vitro biological models to test the effects of compound injection in the subcutaneous tissue. Formulations are generally tested in vivo on animals, even though their skin and subcutaneous fat tissue are different from humans. The absence of more pertinent models makes it difficult to evaluate and optimize a compound’s formulation before clinical trials. To develop efficient drugs for subcutaneous injection, there’s a strong need for in vitro experimental models that closely mimic human tissue structure and physiology.
HypoSkin® comes in different sizes and thickness to meet any study need
HypoSkin® comes in a range of formats varying in biopsy diameter and fat tissue thickness to assess skin response to subcutaneous injection and topical or systemic administration.
Please note that the successful use of HypoSkin® assays requires training. We would be happy to discuss it with you and help your project move forward: contact us for additional information.
|SUBCUTANEOUS INJECTION||TOPICAL ADMINISTRATION|
|REFERENCE||DESCRIPTION||Ø||HYPODERMIS THICKNESS||RECOMMENDED INJECTION VOLUME||WORKING SURFACE||RECOMMENDED TOPICAL VOLUME||EX VIVO CULTURE DURATION||PLATE FORMAT||REQUIRED VOLUME OF MEDIUM/DAY||MINIMUM ORDER|
|HPS001-5||HypoSkin®||11 mm||5 mm||-||0.5 cm2||5-20 uL||7 days||12 wells||1 mL||12 wells|
|HPS001-10||10 mm||20 uL|
|HPS002-5||HypoSkin® Medium||15 mm||5 mm||-||1.13 cm2||25-45 uL||7 days||6 wells||2 mL||12 wells|
|HPS002-10||10 mm||40 uL|
|HPS003-5||HypoSkin® Large||20 mm||5 mm||-||1.76 cm2||50-70 uL||7 days||6 wells||2 mL||12 wells|
|HPS003-10||10 mm||100 uL|
|HPS004-5||HypoSkin® XL||23 mm||5 mm||-||2.54 cm2||100-200 uL||5 days||6 wells||3 mL||12 wells|
|HPS004-10||10 mm||125 uL|