Publications

DATA, DATA EVERYWHERE

Discover through our various publications how Genoskin intends to help science move forward using cutting-edge technology. Our Research & Development activity leads us to the creation of more innovative skin models with high predictive value. We aim to broaden our already wide range of applications to help industries to test their products with models adapted to their needs. Our research mainly focuses on skin metabolism and pathological skin models.

InflammaSkin®, study of the efficacy of anti-inflammatory treatment

Hypo-InflammaSkin® model

Evaluation of pharmacological responses to subcutaneous injection of adalimumab in InflammaSkin®

Genoskin newly developed InflammaSkin®, a T cell-driven skin inflammation model for psoriasis. With adipose, this cutting-edge assay is designed to assess the efficacy of subcutaneously-delivered anti-inflammatory treatments.

NativeSkin®, maintaining skin integrity and metabolism

Photograph illustrating publications of skin metabolism. It shows NativeSkin model, a standardized and ready-to-use human skin model.

NativeSkin® maintains normal human skin integrity and metabolism during 10 days in culture

For the first time, we demonstrated that NativeSkin® can be cultured for up to 10 days while preserving normal skin integrity, significant cell viability,  proliferative cells and low levels of apoptosis. Our next step will be to evaluate the activity of specific human skin cytochromes involved in the metabolization of drugs topically applied on NativeSkin®.

Woundskin®, an innovative model to study wound healing

Illustration of Woundskin model

An ex vivo human skin model for healing of infected wound

Wounded HypoSkin® model is suitable to study wound infection. This model presents the ability to evaluate topical therapies and dressings in prophylactic administration, to prevent wound infection, or in therapeutic treatment, for infected wounds.

HypoSkin®, a new model to study microbiome

Photograph illustrating publications of a skin microbiome poster. It shows two models of HypoSkin, a unique skin model with epidermis, dermis and hypodermis.

A fully functional ex vivo human skin model to study human skin microbiome

HypoSkin® is a fully functional ex vivo human skin model that is relevant to study human skin microbiome and to assess changes in skin microbiota following treatment with dermo-cosmetic products.

InflammaSkin®, evaluation of anti-psoriasis treatment

illustration showing Genoskin's InflammaSkin model for publications

Evaluation of pharmacological responses in InflammaSkin® a human ex vivo skin model reproducing key features of psoriasis

InflammaSkin® is a T-cell driven ex vivo human psoriasis skin model to test anti-inflammatory drugs. This skin model can be used to assess pharmacological responses following topical prophylactic and therapeutic treatments.

NativeSkin®, an immunocompetent skin model to study antigen uptake

Photo illustrating NativeSkin publications: immunostaining of treatment with via skin

NativeSkin®, an immunocompetent human skin model to study antigen uptake and processing by Langerhans cells

NativeSkin® is a patented human skin model reproducing the complexity of real live human skin. It allows culture, treatment, and manipulation of human skin for research and analysis. This model can be used to predict human skin response to treatments. In particular, the presence of immune cells enables the study of allergen uptake during epicutaneous immunotherapy.

Light-sheet microscopy technology, in-depth skin structure visualization

LSFM 3D imaging of a full-thickness skin biopsy

3D imaging of cleared ex vivo normal human skin, skin appendages and psoriasiform skin lesion using light-sheet microscopy

Light-sheet fluorescence microscopy (LSFM) is an attractive approach that has shown promise for acquisition of volumetric data of thick tissues. When combined with optical clearing methods, LSFM allows in-depth optical sectioning and generation of 3D images of entire human skin biopsies.

HypoSkin®, skin model for subcutaneous injections

Injection of blue colorant into HypoSkin, one of our ex vivo human skin models

Evaluation of inflammatory reactions following subcutaneous injection of a pro-inflammatory cocktail in a human ex vivo skin model

HypoSkin® is the only human skin model to study subcutaneous injections. It contains all three layers of human skin, i.e. epidermis, dermis and hypodermis with normal fat tissue architecture.  This model enables the evaluation of local inflammatory reactions following subcutaneous injection of formulations.