DATA, DATA EVERYWHERE
Discover through our various publications how Genoskin intends to help science move forward using cutting-edge technology. Our Research & Development activity leads us to the creation of more innovative skin models with high predictive value. We aim to broaden our already wide range of applications to help industries to test their products with models adapted to their needs. Our research mainly focuses on skin metabolism and pathological skin models.
NativeSkin®, maintaining skin integrity and metabolism
For the first time, we demonstrated that NativeSkin® can be cultured for up to 10 days while preserving normal skin integrity, significant cell viability, proliferative cells and low levels of apoptosis. Our next step will be to evaluate the activity of specific human skin cytochromes involved in the metabolization of drugs topically applied on NativeSkin®.
Woundskin®, an innovative model to study wound healing
Wounded HypoSkin® model is suitable to study wound infection. This model presents the ability to evaluate topical therapies and dressings in prophylactic administration, to prevent wound infection, or in therapeutic treatment, for infected wounds.
NativeSkin®, an immunocompetent skin model to study antigen uptake
NativeSkin® is a patented human skin model reproducing the complexity of real live human skin. It allows culture, treatment, and manipulation of human skin for research and analysis. This model can be used to predict human skin response to treatments. In particular, the presence of immune cells enables the study of allergen uptake during epicutaneous immunotherapy.
Light-sheet microscopy technology, in-depth skin structure visualization
Light-sheet fluorescence microscopy (LSFM) is an attractive approach that has shown promise for acquisition of volumetric data of thick tissues. When combined with optical clearing methods, LSFM allows in-depth optical sectioning and generation of 3D images of entire human skin biopsies.
HypoSkin®, skin model for subcutaneous injections
HypoSkin® is the only human skin model to study subcutaneous injections. It contains all three layers of human skin, i.e. epidermis, dermis and hypodermis with normal fat tissue architecture. This model enables the evaluation of local inflammatory reactions following subcutaneous injection of formulations.