22
Feb

Using NativeSkin® to study poison ivy-induced dermatitis

Using NativeSkin® to evaluate poison ivy effects  A couple of months ago, Genoskin’s team started to wonder: “Why not try to better understand poison ivy dermatitis through our NativeSkin® model ?” In this article, we summarize information about what is known regarding the poison ivy reaction and what happens on a macroscopic level when poison ivy toxin is applied to
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13
Jan

Genoskin reproduces ex vivo the process of apomorphine-induced panniculitis

Study of apomorphine-induced panniculitis in HypoSkin® model Apomorphine is a well-known molecule used in the treatment of Parkinson's disease (PD) symptoms. It is commercially available as apomorphine hydrochloride under the brand names Apokyn or Kynmobi. Apomorphine has the potential to positively impact patients' quality of life. However, some of its adverse effects are hard to manage and might lead to
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30
Nov

Human connective tissue mast cells

Human connective tissue mast cells A cellular model to better understand the underlying mechanisms of Injection Site Reactions (ISRs) and other severe allergic reactions. Mast cell culture assays are critical to better understand the kinetics and dynamics underlying inflammatory reactions. Genoskin’s team of experts has developed a method to grow connective tissue-type mast cells (CTMCs) derived from the peripheral blood
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20
Nov

Top things found in human skin!

Top things found in human skin (vs in reconstructed human skin models) Skin is our largest organ (2m2). Since the skin is a mandatory test organ for regulatory agencies, every single drug in development needs to be tested for potential skin toxicity. Today, efficacy and safety studies are performed either on animal skin, reconstructed skin, or ex vivo human skin.
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28
Oct

A unique ex vivo perfused human skin model to test pharmacokinetic and systemic administration in human skin

The FlowSkin® platform : a unique ex vivo perfused human skin model to test pharmacokinetic and systemic administration in human skin When human tissue culture meets microfluidic technology, it leads to the first perfused human skin model ; an amazing platform to overcome the challenges of drug development and replace animal testing. Almost 10 years ago now, Genoskin developed the
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16
Oct

Genoskin awarded the Healthtech prize “Transformons la France!”

Genoskin awarded the Healthtech prize “Transformons la France!” Yesterday, Genoskin was awarded the Healthtech prize at the “Transformons la France!” (Let’s Transform France!) ceremony presented by La Tribune in Toulouse. While the current health crisis calls into question our lifestyles, "Transformons la France!" highlights the talents of tomorrow and gives impact to those who transform society for the better. The
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